Endep (amitriptyline)

Antidepressant Medication

When Is It Prescribed?

Endep (amitriptyline) is prescribed to treat depression.

This medication is also used to manage chronic, severe pain; help ease agitation; and treat intractable hiccups.

Endep, a trycyclic antidepressant (TCA), works by bringing the levels of the neurotransmitter norepinephrine to normal levels.

This medication may also be prescribed for purposes other than what’s listed above.


When Will It Start to Work?

It may take one to two weeks before you begin to feel better. The time it takes to experience the full effects of Endep depends on dosage and varies from person to person.

There are withdrawal symptoms associated with this medication. Endep (amitriptyline) should be slowly discontiued over a period of time under your doctor's or therapist's supervision.


Are There any Drug Interactions?

Always follow your prescribing doctor's or therapist's recommendations on how to take your medication and be sure and let them know if you are taking any other prescription medications, herbal remedies, vitamins, and/or over-the-counter medications.


Pregnancy and Breastfeeding Issues

If you are pregnant, plan to become pregnant, or are breastfeeding, discuss the potential risks of this or any medication with your prescribing doctor or therapist.


Other Important Information and Precautions

Before taking amitriptyline, tell your doctor if you have:

  • Liver or kidney disease

  • Asthma

  • Thyroid disease

  • Diabetes

  • Stomach or intestinal problems

  • Had a heart attack in the last 6 weeks

  • An enlarged prostate or difficulty urinating

  • Glaucoma

You may not be able to take amitriptyline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Who Should Not Take Amitriptyline?

Do not take amitriptyline if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) within the last 14 days.

In addition to the information listed above, there may be other important issues or precautions related to this medication. For further information, you can ask your prescribing doctor or therapist.


Side-Effect Information

Only some people will experience side-effects -- and no one experiences side-effects in exactly the same way. If you experience any side-effects, contact your doctor or therapist right away and continue taking your medication.

If you are over 60 years of age, you may be more likely to experience such side-effects as drowsiness, dizziness, unsteadiness, feeling uncoordinated, and/or low blood pressure, and may require a lower dose of this medication.

The following list may not contain all of the side-effects associated with this medication:

Most Common Side-Effects drowsiness, dizziness, insomnia, blurred vision, rash, dry mouth
Infrequent Side-Effects photosensitivity, agitation, diarrhea, high blood pressure, hair loss, increased or decreased libido, nausea, sweating, swelling, weight gain or loss, worsening of paranoid psychosis in schizophrenic patients
Rare Side-Effects/Risks seizures, delirium, delusions, hallucinations, Tourette syndrome, liver/kidney toxicity, heart rhythm disturbances, abnormally low white blood cell and platelet count, tremors, nightmares

Side-effects and risks other than those listed above may also occur. Talk to your prescribing doctor or therapist about any potential or existing side-effects that you’re concerned about.


Every effort has been made to ensure that the information provided by 4therapy.com is accurate and up-to-date, but no guarantee is made to that effect.

4therapy.com’s medication information is a reference resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge, and judgment of healthcare practitioners in patient care. 4therapy.com does not assume any responsibility for any aspect of healthcare administered with the aid of information 4therapy.com provides.