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Marplan (isocarboxazid)

Antidepressant Medication

When Is It Prescribed?

Marplan (isocarboxazid), is a medication that is used to treat depression.

Marplan is a monoamine oxidase inhibitor. This medicine works by increasing the concentration of the neurotransmitters epinephrine, norepinephrine, and serotonin, thereby relieving the symptoms of depression.

This medication may also be prescribed for purposes other than what’s listed above.


When Will My Medication Start to Work?

Usually, it takes between 48 hours to three weeks to achieve the full effect.


Are There Any Drug Interactions?

Always follow your physician's or therapist's recommendations on how to take your medication. If you are taking any other prescription medications, herbal remedies, vitamins, and/or over-the-counter medications, be sure to tell your physician or therapist.


Pregnancy and Breastfeeding Issues

If you are pregnant, plan to become pregnant, or are breastfeeding, discuss the potential risks of this or any medication with your doctor or therapist.


Other Important Information and Precautions

Marplan (isocarboxazid) should not be administered in combination with any of the following:

  • MAO inhibitors or dibenzazepine derivatives

  • Sympathomimetics (including amphetamines)

  • Some central nervous system depressants (including narcotics and alcohol)

  • Antihypertensive, diuretic, antihistaminic, sedative or anesthetic drugs

  • Buproprion HCL

  • Buspirone HCL

  • Dextromethorphan

  • Cheese or other foods with a high tyramine content

  • Excessive quantities of caffeine

Marplan (isocarboxazid) should not be administered to any patient with a confirmed or suspected cerebrovascular defect or to any patient with cardiovascular disease, hypertension, or history of headache.

In addition to the information listed above, there may be other important issues or precautions related to this medication. For further information, you can ask your prescribing doctor or therapist.


Side-Effect Information

Only some people will experience side-effects -- and that no one experiences side-effects in exactly the same way. If you experience any side-effects, contact your doctor or clinician right away and continue taking your medication.

The following list may not contain all of the side-effects associated with this medication:

Most Common Side-Effects dizziness, headache, dry mouth, constipation
Infrequent Side-Effects drowsiness, anxiety, naseau
Rare Side-Effects/Risks diarrhea, urinary frequency, tremor, sweating, syncope

Side-effects and risks other than those listed above may also occur. Talk to your prescribing doctor or therapist about any potential or existing side-effects that you’re concerned about.


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